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A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults
Chandrasekhar K, Kapoor J, Anishetty S
Indian J Psychol Med, 2012
Key Finding: 27.9% reduction in serum cortisol levels with 600mg daily ashwagandha extract
A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera
Andrade C, Aswath A, Chaturvedi SK, Srinivasa M, Raguram R
Indian J Psychiatry, 2000
Key Finding: 88.2% response rate in anxiety disorder treatment
Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S
J Int Soc Sports Nutr, 2015
Key Finding: 96.2 ng/dL increase in testosterone; significant gains in muscle strength and size
A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha extract on sleep quality in healthy adults
Deshpande A, Irani N, Balkrishnan R, Benny IR
Sleep Med, 2020
Key Finding: 72% improvement in sleep quality compared to placebo
Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial
Sharma AK, Basu I, Singh S
J Altern Complement Med, 2018
Key Finding: Normalized TSH, T3, and T4 levels in subclinical hypothyroid patients
Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males
Ahmad MK, Mahdi AA, Shukla KK, Islam N, Rajender S, Madhukar D, Shankhwar SN, Ahmad S
Fertil Steril, 2010
Key Finding: Improved sperm count, motility, and reproductive hormone levels
Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
Choudhary D, Bhattacharyya S, Bose S
J Diet Suppl, 2017
Key Finding: Significant improvements in immediate and general memory, executive function, and attention
A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults
Tiwari S, Gupta SK, Pathak AK
J Ethnopharmacol, 2021
Key Finding: Improved VO2 max and cardiorespiratory endurance in athletes
Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial
Choudhary D, Bhattacharyya S, Joshi K
J Evid Based Complementary Altern Med, 2017
Key Finding: Reduced body weight and BMI in chronically stressed adults
Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study
Dongre S, Langade D, Bhattacharyya S
Biomed Res Int, 2015
Key Finding: Improved sexual function and arousal in women
Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial
Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, Gholampour F, Mohammadpour AH, Sahebkar A
Complement Ther Med, 2016
Key Finding: Reduced OCD symptoms in clinical trial
Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants
Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S
J Clin Med, 2021
Key Finding: Enhanced natural killer cell activity and immune function
A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study
Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S
JANA, 2008
Key Finding: Reduced CRP and inflammation markers in chronically stressed individuals
Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root
Andallu B, Radhika B
Indian J Exp Biol, 2000
Key Finding: Improved insulin sensitivity and reduced blood glucose levels
A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males
Lopresti AL, Drummond PD, Smith SJ
Am J Mens Health, 2019
Key Finding: Increased DHEA-S and testosterone in aging males
Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial
Ziegenfuss TN, Kedia AW, Sandrock JE, Raub BJ, Kerksick CM, Lopez HL
Nutrients, 2018
Key Finding: Enhanced strength training adaptations and muscle recovery
Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder
Chengappa KNR, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R
J Clin Psychiatry, 2013
Key Finding: Improved cognitive function in bipolar disorder patients
Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants
Pingali U, Pilli R, Fatima N
Pharmacognosy Res, 2014
Key Finding: Improved reaction time and psychomotor performance
Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study
Chengappa KNR, Brar JS, Gannon JM, Schlicht PJ
J Clin Psychiatry, 2018
Key Finding: Reduced symptom exacerbation in schizophrenia patients
Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum
Bhattacharya A, Ghosal S, Bhattacharya SK
J Ethnopharmacol, 2001
Key Finding: Demonstrated antioxidant and neuroprotective effects
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